How to from rabb.it2/24/2023 ![]() It is a cytosolic protein, which is up-regulated in response to many factors, including metals, hormones, inflammation related stimuli (cytokines), and stressful reagents. Much of our understanding of the biological actions of MTs has arisen from the comparative analysis of the chemical and structural features. ![]() Monovalent metal ions like Cu(I) can form a cluster as well, via thiolate bonds. The beta-domain contains an analogous Me 3Cys 9 cluster. The alpha-domain encloses four bivalent metal ions in the form of a Me 4Cys 11 cluster. The 3D structure of the metal complex contains two separate domains, alpha and beta. They are similar in sequence and therefore also in charge. The MT-1 fraction contains additional MT isoforms, which differ only in amino acid residues other than Cys. It is composed of a single polypeptide chain of 61 amino acids, 20 of which are cysteine residues and none of which are aromatic amino acids or histidine. ![]() MT-1 is an isoform of the ubiquitously occurring metalloproteins characterized by a high metal and cysteine sulphur content. For cell culture studies, please use Prod. Metallothionein-1 containing zinc and cadmium ions. ![]()
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